The expression patterns and functional relevance of the top sex-specific network driver of AD were further investigated using postmortem human brain samples and gene perturbation experiments in AD mouse models. We integrated large-scale human postmortem brain transcriptomic data of AD from two cohorts (MSBB and ROSMAP) via multiscale network analysis and identified key drivers with sexually dimorphic expression patterns and/or different responses to APOE genotypes between sexes. ![]() Therefore, we applied systems biology approaches to investigate sex-specific molecular networks of AD. Moreover, while the interplay between sex and ApoE genotype in AD has been investigated, multi-omics studies to understand this interaction are limited. However, the underlying mechanisms are poorly characterized. ![]() Alzheimer’s disease (AD) is a progressive and age-associated neurodegenerative disorder that affects women disproportionally.
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